Synthetic neuropeptide research compound for controlled laboratory studies.
- Dose
- 10 mg
- Batch
- 268013
Semax
Semax — L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolyl-glycyl-L-proline (ACTH(4-7)PGP) · MEHFPGP
For research purposes only — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Synthetic neuropeptide research compound for controlled laboratory studies.
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- Lab
- Janoshik Analytical
- Purity
- 99.44%
- Methods
- HPLC · LC-MS
- Tested
- Oct 2, 2026
For laboratory research use only. Not for human consumption.
Technical specifications
- Type
- Peptide
- Scientific name
- Semax — L-methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolyl-glycyl-L-proline (ACTH(4-7)PGP)
- Amino acids
- 7
- Sequence
- MEHFPGP
- Molecular weight
- 813.9 g/mol
- Formula
- C37H51N9O10S
- CAS
- 80714-61-0
- Origin
- Synthetic heptapeptide: the ACTH(4-7) fragment Met-Glu-His-Phe extended at the C-terminus with the stabilizing tripeptide Pro-Gly-Pro; commonly described in the literature as an ACTH(4-10) analogue.
- Lyophilized (powder)
- -20°C, desiccated and protected from light · stable long-term; -80°C for multi-year storage
- Reconstituted
- 2-8°C · use within ~30 days; aliquot and store at -20°C to avoid repeated freeze-thaw cycles
- Room temperature
- Lyophilized powder tolerates short room-temperature excursions such as shipping, but is not suitable for routine ambient storage. In solution the peptide degrades quickly at room temperature — the Met residue is prone to oxidation and the unprotected termini to hydrolysis and peptidase cleavage — so reconstituted material should not be left at ambient temperature.
Peer-reviewed research
Published research and registered trials involving this compound. Provided for educational reference only — none of it is a claim about this product.
- Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova[Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]Gusev EI, Skvortsova VI, Miasoedov NF, Nezavibat'ko VN, Zhuravleva EIu, Vanichkin AV1997PMID: 11517472
- Neurochemical ResearchSemax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodentsEremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS2005DOI: 10.1007/s11064-005-8826-8PMID: 16362768
- Brain ResearchSemax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusDolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Kamensky AA, Grivennikov IA, Myasoedov NF, Engele J2006DOI: 10.1016/j.brainres.2006.07.108PMID: 16996037
- Journal of NeurochemistrySemax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrainDolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, Kamensky AA, Grivennikov IA, Engele J, Myasoedov NF2006DOI: 10.1111/j.1471-4159.2006.03658.xPMID: 16635254
- BMC GenomicsThe peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysisMedvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV2014DOI: 10.1186/1471-2164-15-228PMID: 24661604
- Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN2018DOI: 10.17116/jnevro20181183261-68PMID: 29798983
- Bulletin of Experimental Biology and MedicineEffects of Semax on the Default Mode Network of the BrainLebedeva IS, Panikratova YR, Sokolov OY, Kupriyanov DA, Rumshiskaya AD, Kost NV, Myasoedov NF2018DOI: 10.1007/s10517-018-4234-3PMID: 30225715
- International Journal of Molecular SciencesBrain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-ReperfusionSudarkina OY, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Valieva LV, Remizova JA, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV2021DOI: 10.3390/ijms22126179PMID: 34201112
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